• Published results have revealed relationships between serine

  2019-11-18

  

  Published results have revealed relationships between serine 81 in AR and some CDKs, especially CDKs 1, 5 and 9 [12], [13], [14], [15], [16]. These results are often supported by pharmacological inhibition of a certain CDK. An effect of CDK1 inhibition on suppression of S81-phosphorylation was previ

• On the opposite side sPLA X

  2019-11-18

  

  On the opposite side, sPLA2-X has also been implicated in the pathology of cancer [167,168]. Human sPLA2-X induces lipid droplet formation in Ras-driven MDA-MB-231 triple-negative breast cancer Irinotecan HCl Trihydrate and promotes their survival during nutrient stress. It acts through the products

• In general cellular senescence is

  2019-11-18

  

  In general, cellular senescence is considered a programmed response to stress that can be activated by oxidative stress, irradiation or action of substances or drugs. These stressors cause DNA damage and, through the action of specific proteins (p53 and p21), lead to cell senescence (di Fagagna, 200

• br Materials and methods br Results br

  2019-11-18

  

  Materials and methods Results Discussion In our tissue array, we demonstrated that 14-3-3 tau mRNA and protein expression levels decreased in the preeclamptic placentas. 14-3-3 proteins are considered to be important in the functional regulation of trophoblasts and maybe associated with adv

• Two nutrient sensing pathways the cAMP

  2019-11-18

  

  Two nutrient-sensing pathways, the cAMP-protein kinase A (PKA) pathway and the target of rapamycin complex 1 (TORC1) pathway, are implicated in Msn2/4 regulation. Under non-stress conditions, Msn2 localizes in the cytoplasm and is inactivated by both PKA-dependent phosphorylation of the nuclear loca

• br Introduction Myotonic dystrophy dystrophia myotonica DM i

  2019-11-18

  

  Introduction Myotonic dystrophy (dystrophia myotonica, DM) is an autosomal dominant disorder and the most common form of inherited muscular dystrophy in adults [1]. DM is characterised by a wide range of symptoms, including myotonia, progressive muscle loss, cataracts, cardiac conduction defects,

• Taking all the data together

  2019-11-18

  

  Taking all the data together, we propose the possible mechanism of glyphosate-induce cell proliferation via estrogen receptor signaling (Fig. 10). Glyphosate may bind to ERα followed by an activation step that starts with the phosphorylation of ERα and activation of other signaling proteins by phosp

• br The modulation of ER from SERMs to TSECs

  2019-11-18

  

  The modulation of ERα: from SERMs to TSECs Continued efforts to provide women with efficacious menopausal therapies have generated interest in the development of selective Furosemide receptor modulators (SERMs). Similar to estrogens, SERMs have been shown to bind to ERs with high affinity, despit

• Enhanced oxidative stress has been suggested as the critical

  2019-11-18

  

  Enhanced oxidative stress has been suggested as the critical mechanisms of IS-produced muscle damage [41,42]. NAC as a direct reactive oxygen species ROS scavenger is frequently discussed in the clinical trials of radiocontrast-induced AKI prevention [43]. Despite some supportive epidemiological dat

• br Ubiquitination and deubiquitination pathways Ubiquitinati

  2019-11-18

  

  Ubiquitination and deubiquitination pathways Ubiquitination is a part of the post-translational modification (PTM) process. Ubiquitination affects proteins in various ways, but its main functions are to signal protein degradation via the 26S proteasome, modify cellular location of proteins, affec

• Structural changes within the heteromer induced by agonist a

  2019-11-18

  

  Structural changes within the heteromer induced by agonist administration show a high level of complication. The presented results obtained in quantitative FLIM-FRET measurements with two selective ligands match the qualitative conclusions indicated by changes in the intracellular calcium level. The

• Ponceau S Staining Solution It is important to note that CRF

  2019-11-16

  

  It is important to note that CRF1 may be activated during acute stress and early phases of anxiety disorders (Coric et al., 2010, Ising et al., 2007), as well the administration of Astressin 2B into the lateral septum did not have an effect on anxiety-like behavior in low-stress conditions but had a

• br How does DDR receptor

  2019-11-16

  

  How does DDR2 receptor activated to induce Osteoarthritis Alternation of joints by mechanical stress produces microcracks and deterioration of natural pores in subchondral bone provides SGC-CBP30 for cross talk through diffusion of small molecules [26,27]. At early stage of OA, chondrocytes in t

• Enolases are among the most

  2019-11-16

  

  Enolases are among the most abundantly expressed cytosolic proteins. They are metalloenzymes that catalyze the conversion of 2-phosphoglycerate to phosphoenolpyruvate [18]. Eubacteria and archaebacteria have a single enolase gene (reviewed in [19]). Despite the lack of signal peptides or cognate pro

• Intriguingly our laboratory has shown that

  2019-11-16

  

  Intriguingly, our laboratory has shown that the I638F kinase domain mutant, unlike the L63V and G505 mutants, is incapable of receptor autophosphorylation and activation of its downstream effector SHP-2 when exposed to collagen stimulation. These data indicate that I638F is a loss of function mutati

16484 records 956/1099 page Previous Next First page 上5页 956957958959960 下5页 Last page