• The biological actions of ET are

  2021-08-17

  

  The biological actions of ET‐1 are mediated via two distinct receptor subtypes, the endothelin A and endothelin B receptors (ETA/ETB). While activation of ETA is assumed to mediate contraction of smooth muscle cells, the activity of ETB is related to transient vasodilation [22]. In human corpus cave

• The expression of EBI has been found to be

  2021-08-17

  

  The expression of EBI2 has been found to be dysregulated in several types of B cell malignancies and is thus reduced in e.g. diffuse large B-cell lymphomas [12] and chronic lymphocytic leukemia [13] and increased in post-transplantation lymphoproliferative disorders (PTLDs) [14]. EBI2 is also highly

• br Acknowledgements We thank Dr James Ritchie

  2021-08-17

  

  Acknowledgements We thank Dr. James Ritchie and his dedicated staff (Deptartment of Pathology, Emory University) for performing measures of serum VPA levels; Sumitomo Pharmaceuticals (Osaka, Japan) for the generous donation of DOPS, which is required for breeding Dbh −/− mice; Pfizer (Sandwich, K

• The data from the Sur lab have showed

  2021-08-16

  

  The data from the Sur lab have showed DNA-PK is involved in metabolic gene regulation in response to insulin. DNA-PK regulates fatty c-di-AMP synthesis by modulating the protein expression of fatty acid synthase (FAS) in a feeding-dependent manner. DNA-PK induces the activation of Upstream Stimulato

• br Concluding remarks A crucial step in the microbial degrad

  2021-08-16

  

  Concluding remarks A crucial step in the microbial degradation of steroids is the 1(2)-dehydrogenation of the steroid nucleus by FAD-dependent Δ1-KSTDs. This step is required to initiate the opening of the steroid nucleus under both aerobic and anaerobic conditions. A large variety of steroid-deg

• One of the most frequent gene alterations

  2021-08-16

  

  One of the most frequent gene alterations in MM is methylation of the p15 and p16 genes in the 5′ upstream region. P15 and p16 proteins are Y-27632 regulators involved in the inhibition of transition from G1 to S phase. Frequencies of p15 or p16 gene methylation up to 32% and 53%, respectively, ha

• br Introduction The allergic response

  2021-08-16

  

  Introduction The allergic response is a complex process involving the interaction of several mediators; among these, cysteinyl leukotrienes (CysLTs) represent one of the most important actors in the pathogenesis of airway allergic diseases such as allergic rhinitis and asthma [1]. Pharmacological

• The on target in vitro pharmacology of was

  2021-08-16

  

  The on target in vitro pharmacology of 18 was then further explored, first in respect of murine CRTh2 receptor activity (Table 5), where similar levels of activity were found in both a binding and functional assay compared with the human orthologue, consistent with our earlier observations in the su

• Survival analysis has been widely used in medical science

  2021-08-16

  

  Survival analysis has been widely used in medical science, economics, finance, and social science, among others. In many studies, survival data have primary outcomes or responses that are subject to censoring. The Cox model [7], [8] is the most commonly used regression model for survival data, and t

• ClC is a member of the voltage

  2021-08-16

  

  ClC-3 is a member of the voltage-gated chloride channel superfamily and has many roles in cell proliferation, apoptosis, (S)-(-)-Propranolol hydrochloride progression and so on (Dai et al., 2005). A growing number of studies showed that ClC-3 encoded a volume-regulated Cl− channel (ICl,Vol) in heart

• Estrogens Definition and history The

  2021-08-16

  

  Estrogens: Definition and history The term “estrogens” refers to a group of female hormones, including estrone, estradiol, estriol, and estretrol (Fig. 1). Chemically, estrogens belong to the family of organic compounds known as steroids. As such, their core structure is composed of 17 carbon-carbo

• The ERR gene lacks the typical TATA and CAAT boxes

  2021-08-16

  

  The ERRα gene lacks the typical TATA and CAAT boxes, but has multiple consensus Sp1 binding elements in the GC-rich promoter (Shi et al., 1997). Previously, our laboratory has shown that ERRα expression is upregulated in the mouse uterus by estrogen (Shigeta et al., 1997) and recently we identified

• br Introduction Prostaglandins are important local mediators

  2021-08-16

  

  Introduction Prostaglandins are important local mediators in a host of reproductive processes including ovulation, fertilization, embryonic development, luteal regression, and parturition (Ushikubi et al., 2000). Prostaglandin E2 (PGE2) is among the more versatile prostanoids, and its effects app

• br Materials and methods br Results and discussion br Conclu

  2021-08-16

  

  Materials and methods Results and discussion Concluding remarks Enzymatic production of bioactive 9-cis-11-trans-conjugated linoleic 6-Hydroxydopamine hydrobromide synthesis is part of a detoxification mechanism against linoleic acid which is a toxic and stress factor for many lactic bacter

• In Fig results of this

  2021-08-16

  

  In Fig. 1 results of this experiment are shown as the contour plots of endopeptidase activity. Optimal for the enzyme production by this strain concentrations of peptone and inorganic phosphate were found to be 24 and 0.3g/l, respectively. For specific activity, the optima close to those for glutamy

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