• Following nerve injury Shh expression is upregulated

  2022-02-17

  

  Following nerve injury, Shh expression is upregulated in neuronal cell bodies of the facial and sciatic nerves. Additionally, Shh appears to be required for normal regeneration in vivo, and promotes motor neuron survival in vitro (Martinez et al., 2015; Akazawa and Kohsaka, 2007). Based on these obs

• The typical pharmacophore for GPR agonists contains four par

  2022-02-17

  

  The typical pharmacophore for GPR40 agonists contains four parts: head (acid moiety), central (phenyl ring), linker and tail (aromatic carbocyclic or heterocyclic ring) [20]. On the other hand, the chemical features that are required for the PPARγ agonists include hydrogen bond donors and acceptors

• Hippocampal lesioned mice were less

  2022-02-17

  

  Hippocampal-lesioned mice were less able to withhold responding during a DRL-10 requirement (i.e. when the animals had to wait 10s between lever presses), and were thus less efficient than sham operated controls. In contrast, GluR-A−/− mice did not differ from wild-type mice when the DRL requirement

• br Conclusions br Conflicts of Interest br Acknowledgments

  2022-02-17

  

  Conclusions Conflicts of Interest Acknowledgments The Section of Endocrinology and Investigative Medicine is funded by grants from the Medical Research Council (MRC), Biotechnology & Biological Sciences Research Council (BBSRC), National Institute for Health Research (NIHR), an Integrative

• Introduction Glucose dependent insulinotropic polypeptide GI

  2022-02-17

  

  Introduction Glucose-dependent insulinotropic polypeptide (GIP) is a hormone secreted postprandially from enteroendocrine K cells in response to ingestion of either fat [1], protein [2], or carbohydrates [3]. GIP is primarily known for its glucose-dependent insulinotropic actions mediated via the G

• Our own search towards aryl

  2022-02-17

  

  Our own search towards aryl-imidazole derived GSMs led to the discovery of the benzimidazole derivative (). It is one of the most potent GSMs to date, suffering however from sub-optimal drug-like properties. More recently, we have described the design and synthesis of bicyclic triazolo-derivatives,

• Further insight in how exactly galanin

  2022-02-17

  

  Further insight in how exactly galanin might inhibit seizures was obtained from galanin transgenic mice. It occurred that the altered susceptibility to seizures was in direct correlation with glutamate release from hippocampal slices obtained from these animals (Fig. 2(b)). While no differences were

• ezh2 inhibitor br Materials and methods br Results br Discus

  2022-02-16

  

  Materials and methods Results Discussion The COMPASS family of histone methyltransferases exhibits HMT activity towards histone 3 lysine 4 residue with KMT2F and KMT2G being the major H3K4 methylases (Shilatifard, 2006). They play an important role in the formation and progression of leukem

• Successful immune escape will be

  2022-02-16

  

  Successful immune escape will be then followed by cancer development, along with which immunocytes infiltration occurs. While some immunocytes are born to sweep away the malignancy, others aim to neutralize the lethality and sustain immune anergy and tolerance [59,60]. And the latter one is well rep

• The data presented here support a dynamic and

  2022-02-16

  

  The data presented here support a dynamic and complex interplay among labile heme, BACH1 and HO-1. It appears also that metabolites of heme degradation may participate in the mechanistic regulation of the various factors examined. Our results point to the possibility that the HO-1 pathway restricts

• br Background To treat chronic HCV genotype GT infected pati

  2022-02-16

  

  Background To treat chronic HCV genotype (GT) 1-infected patients, telaprevir (TLP) or boceprevir (BOC), first generation protease inhibitors (PIs), were used in combination with pegylated-interferon (PEG-IFN) and ribavirin (RBV) triple therapy [1], [2]. The main weaknesses of the first-generatio

• br Transparency declaration br Acknowledgements

  2022-02-16

  

  Transparency declaration Acknowledgements Hepatitis C Virus (HCV) infection represents a disease of significant global impact that afflicts around 170 million people worldwide., A small proportion of infected people clear the virus naturally, whilst the majority develop chronic hepatitis C

• The following are the supplementary

  2022-02-16

  

  The following are the supplementary data related to this article. Transparency Document Acknowledgements Introduction Nitric oxide (NO) is an important signaling molecule mediating several physiological functions including vasodilation, platelet anti-aggregation, inhibition of interstitial

• br Potential endogenous agonists of

  2022-02-15

  

  Potential endogenous agonists of GPR35 The first endogenously produced chemical that was shown to be able to activate GPR35 was the tryptophan metabolite kynurenic ZD 7288 [8]. When human GPR35 was expressed along with a mixture of promiscuous and chimeric G proteins 9, 10 (Box 1) in CHO cells,

• Milligan et al demonstrated the

  2022-02-15

  

  Milligan et al. [31] demonstrated the important role of TNF-α, IL-6 and IL-1β in the development of mechanical hyperalgesia induced by intrathecal injection of gp120. Because of this work, we decide to produce and purify gp120 to develop biological systems to study pain and behavior in rodents. Intr

16533 records 514/1103 page Previous Next First page 上5页 511512513514515 下5页 Last page