• In another study authors found that

  2024-11-18

  

  In another study, authors found that ADORA1 were present on the intrinsically photosensitive retinal ganglion cell staining (ipRGCs), and application of adenosine to rat retinas reduced light-evoked spiking of ipRGCs through suppression of a cAMP-mediated pathway (Sodhi and Hartwick, 2014). The ipR

• A more versatile cellular delivery system for adenosine was

  2024-11-18

  

  A more versatile cellular delivery system for adenosine was generated by engineering mouse embryonic stem cells to lack both PHA-680632 mg of Adk (Fedele et al., 2004). Using a step-wise differentiation protocol (Okabe et al., 1996) Adk−/− ES cells were differentiated into transplantable adenosine-

• To understand the kinase selectivity

  2024-11-18

  

  To understand the kinase selectivity profile of this series, Anti-cancer Compound Library , as a representative analog from this series, was profiled against 216 purified protein kinases representing the tyrosine and serine/threonine kinase families using an in-house Caliper EZ Reader mobility shift

• Alisol B 23-acetate Bioactive peptides contain amino acids w

  2024-11-18

  

  Bioactive peptides contain 2–20 amino acids with possible bioactivities including antihypertensive, antioxidant, antimicrobial, anticancer, and opioid activity [9], [10], [11]. There has been a great interest in antihypertensive peptides for their efficiency in lowering blood pressure. The antihyper

• A review has recently been

  2024-11-18

  

  A review has recently been published to evaluate the potential effects of food, alcohol and TNKS 49 juices on the pharmacokinetics and pharmacodynamics of the drugs for BPH. The authors reviewed the PubMed database during the years 1991–2015. In addition, a digital version of Stockley on drug inter

• br Conflict of interest br

  2024-11-18

  

  Conflict of interest Introduction Ovarian cancer is the most lethal gynecological malignancy, and ranks as the fifth leading cause of cancer death among women. The American Cancer Society estimates that about 22,280 new ovarian cancer cases and 14,240 deaths will occur in the United States in

• Gliotoxin Loss of virulence in ACL

  2024-11-18

  

  Loss of virulence in ACL mutants may be caused by defect in vegetative growth and conidial germination, and reduced trichothecene production. However, supplement of potassium acetate restored the defects in germination rate and vegetative growth, but not virulence in wheat heads (Table 2, Fig. 2B),

• br Conclusions In the current study

  2024-11-15

  

  Conclusions In the current study, we found that the exposure of maduramicin to chicken myocardial LY364947 results in cellular damage and even death via the induction of apoptosis. Maduramicin upregulated the expression of apoptotic genes and activated caspase cascades, which were accompanied by

• br Consequences of central apelin

  2024-11-15

  

  Consequences of central apelin/APJ modulation Regarding extra-hypothalamic actions, recent data demonstrate that the central apelin/APJ system could be a potential new target for the regulation of memory (Han et al., 2014). Then, intracerebroventricular (icv) apelin administration in mice impairs

• The radiographic correlate will be similarly important for

  2024-11-15

  

  The radiographic correlate will be similarly important for the success of other non-VEGF TKIs, such as those targeting the epidermal growth factor receptor expressed in 50% of high-grade primary Dacarbazine neoplasms. It has been reported that icotinib and gefitinib, epidermal growth factor recepto

• Breast Cancer Although androgens have been considered to be

  2024-11-15

  

  Breast Cancer: Although androgens have been considered to be a risk factor in prostate cancer they have been recommended to treat breast cancers. Even before the discovery of SERMs and aromatase inhibitors, steroidal androgens such as medroxyprogesterone and fluoxymesterone were used to treat breast

• br Conflict of interest statement br Introduction

  2024-11-15

  

  Conflict of interest statement Introduction Tanshinone IIA (Tan IIA) is a major active component of Salvia miltiorrhiza (S. miltiorrhiza), a well-known Chinese traditional medicine that is used for the treatment of cardiovascular and cerebrovascular diseases [1]. Tan IIA exhibits diverse pharm

• br Perspective AA LA and other PUFAs and

  2024-11-15

  

  Perspective AA, LA and other PUFAs and their lipid metabolites play an important role in human diseases. 12/15-LOX which is the metabolic enzyme of them plays an important role in the pathogenesis-related diseases such as atherosclerosis, diabetic nephropathy, neurological diseases and other path

• br Material and methods br Results br Discussion

  2024-11-15

  

  Material and methods Results Discussion RSV is a major cause of lower respiratory tract infections in infancy and early childhood. Several observations suggest that immunological mechanisms may be the key to understand the severity of RSV bronchiolitis in infancy. Several laboratories have

• br Animal models of NAFLD Human

  2024-11-15

  

  Animal models of NAFLD Human research has greatly shaped our understanding of non-alcoholic fatty liver disease, but several limitations exist in studying the disease processes in humans, such as variations in environmental exposure, pre-existing genetic risk factors, racial and ethnic difference

16484 records 51/1099 page Previous Next First page 上5页 5152535455 下5页 Last page