• br Experimental Procedures br Author Contributions br Introd

  2018-11-06

  

  Experimental Procedures Author Contributions Introduction Just as the circulatory system provides nourishment to support tissue and organ function, the larger blood vessels themselves require access to a blood supply to maintain vascular health. The vasa vasorum (Latin: “vessels of the vess

• br H AZ histone exchange H AZ is

  2018-11-06

  

  H2AZ histone exchange H2AZ is incorporated within nucleosomes via ATP-dependent activities. The complexes mediating H2AZ-H2A exchanges are well characterized in Saccharomyces cerevisiae and include the Swr1-containing SWR complex (SWR-C). The mammalian orthologue of Swr1 is SRCAP. Both complexes

• In contrast to Notch Myb

  2018-11-06

  

  In contrast to Notch Myb activation does not affect cyst-like organoid formation, although MybER increases the percentage of isolated crypts capable of forming an organoid and increases adenoma formation in vivo (Malaterre et al., manuscript submitted). Interesting in this context is that MybER indu

• br The important role of the Hippo kinase cascade

  2018-11-06

  

  The important role of the Hippo kinase cascade in suppressing cell proliferation led Heallen, Martin, and colleagues to hypothesize that Hippo signaling deficiency would cause cardiac overgrowth. This hypothesis was supported by the cardiac-restricted inactivation of Mst1/2, Sav1, and Lats2, which

• br Acknowledgment This research was supported

  2018-11-06

  

  Acknowledgment This research was supported by the National Natural Science Foundation of China (Nos. 81371188 and 31170888). Introduction Hematopoietic stem Laminin 925-933 (HSCs) are the only adult stem cells that can sustain lifelong blood cell production through their self-renewal and dif

• MEAs offer the potential for moderate throughput characteriz

  2018-11-06

  

  MEAs offer the potential for moderate-throughput characterization of the electrophysiological and pharmacological properties of iPSC-derived CMs. Analysis of the pharmacological effects of various antiarrhythmic agents provides additional insight into the underlying electrophysiology of these CMs. F

• br Experimental Procedures br Author Contributions br Acknow

  2018-11-06

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Intestinal crypts contain stem cells and their transit-amplifying (TA) daughter cells. Cells exiting the proliferative crypts onto the villi terminally differentiate into enterocytes, goblet cells, and enteroendocr

• br Introduction Human induced pluripotent stem

  2018-11-05

  

  Introduction Human induced pluripotent stem c-met inhibitor (hiPSCs) carry the whole genetic context of a patient and can be a virtually unlimited source of differentiated cell types of interest. Increasingly, hiPSCs are being applied for disease modeling and drug screening for a number of neurod

• One major drawback of current melanoma therapy is

  2018-11-05

  

  One major drawback of current melanoma therapy is the development of resistance mechanisms against novel therapeutics targeting the MAPK members RAF or MEK. Upon MAPK inhibition, additionally acquired mutations reactivate the MAPK pathway by gain of RAF gene copy numbers (Shi et al., 2012; Villanuev

• Our findings directly interface with the

  2018-11-05

  

  Our findings directly interface with the role of CXCL12 (SDF1)/CXCR4 signaling in adult HSPC migration: CXCL12 levels increase in response to stress and inflammation, and influence HSPC mobilization and extravasation within the adult BM (Dar et al., 2006). As hematopoietic niches are hypoxic during

• br Results br Discussion Control

  2018-11-05

  

  Results Discussion Control of cell-cycle progression has been linked to the regulation of self-renewal and cell-fate determination in ESCs (Pauklin and Vallier, 2013; Singh et al., 2015; White and Dalton, 2005). It has been reported that the length of the G1 phase defines the capacity of multi

• br If the quality of vibration suppression

  2018-11-05

  

  If the quality of vibration suppression in the beam proves unsatisfactory, it is necessary to return to identification experiments and additionally determine the subsequent rows of the eigenmode matrices. Next, it is necessary to recalculate the modal matrices according to formula (7) and use them

• Although the findings in this paper contribute

  2018-11-05

  

  Although the findings in this paper contribute new insights to our understanding of the complex relationship between informal care provision and health, nevertheless the study poses certain limitations which necessitate caution in the interpretation of the findings. Firstly, the nature of the data w

• In terms of social environment variables

  2018-11-05

  

  In terms of social environment variables, most studies examined potassium phosphate monobasic cost and safety related variables, finding a positive relationship whereby participants living in socially-cohesive neighbourhoods engaged in more walking, MVPA and overall physical activity but more incon

• While neither chapter is associated with better physical or

  2018-11-05

  

  While neither chapter is associated with better physical or mental health estimates were stronger for Chapter 7 female filers. It may be that there is misalignment with what individuals seek when pursuing assistance and the offerings of the program. For example, a non-negligible portion of Chapter 1

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